Simon Willison (co-creator of Django, coined "prompt injection") talks with Lenny Rachitsky about the November 2025 inflection point when coding agents crossed a reliability threshold, the dark factory pattern where nobody writes or reads code, and the lethal trifecta of AI security risks.
Claude Code 一周岁。它的负责人 Boris Cherny 复盘从"内部 demo 只收到 2 个赞" 到"GitHub 4% 公开 commits、Anthropic 内部人均生产力 +200%"是怎么发生的， 并解释为什么他认为 coding 已经被解决、下一站是让模型自己想做什么、 以及怎么"为 6 个月后的模型"造产品。
Peter Steinberger 讲他怎么在 1 小时内把 WhatsApp 接到 Claude Code 的 CLI, 做出了后来成为 GitHub 史上最快增长仓库的 OpenClaw。围绕这个故事展开的是 agentic engineering 的心法、self-modifying software、Moldbook 引发的 AI psychosis、改名大战、以及他从 PSPDFKit 13 年烧完到重新找回 building 乐趣 的整条弧线。最后谈到下一步可能加入 Meta 或 OpenAI。
Lex Fridman 请来两位"一线做过模型、也写过书"的研究者做 2026 年初的 AI state-of-the-art 盘点: Sebastian Raschka 从 GPT-2 一路手撕到 Qwen3 / Gemma 3, 最擅长从架构里读故事;Nathan Lambert 是 AI2 研究员、RLHF 书作者、atom 项目 发起人,frontier 与 open-source 两边都站过。两人聊了 DeepSeek 时刻、Opus 4.5 神话、RLVR 的"假 aha"、scaling 的三个轴、AI 2027 的时间线推后、Anthropic $1.5B 和解、CUDA 的真护城河、atom project,一直到 100 年后世界的样子。
当世最强的数学家谈他亲手用过 AI 之后的判断：想法生成的成本几乎归零， 但瓶颈搬到了 verification 这一侧；50 道 Erdős 问题被 AI 攻克之后随即陷入瓶颈； AI 像在黑暗中乱跳的机器人，能跨过低墙、爬不上悬崖；breadth × depth 才是 数学的下一步——但要先重设整个学术工作流。
SemiAnalysis CEO Dylan Patel walks through the entire AI compute supply chain, from $600B hyperscaler capex to the 3.5 EUV tools needed per gigawatt. He explains why semiconductors — not power — are the real bottleneck, and what that means for the US-China AI race, memory prices, and consumer electronics.
Professor Renato Renner of ETH Zurich explains his no-go theorem showing quantum theory contradicts itself when applied to observers who are themselves quantum systems. The conversation covers three incompatible assumptions (universality, consistency, single outcomes), a gravity-based escape route involving reference frame loops, the black hole information paradox, and why choosing an interpretation of quantum mechanics is ultimately an emotional decision.
Michael Nielsen and Dwarkesh Patel explore how scientific progress actually happens — from the messy reality of falsification to hostile verification loops that mislead for decades. They discuss why the tech tree is far vaster than we realize, why alien civilizations would develop radically different technologies, and what this means for AI-accelerated science.
Dr. Jenny Wagner explains why gravitational lensing data only constrains local properties of mass distributions, making every grand dark matter map a model-driven extrapolation. She argues the inverse problem approach — reasoning from data to necessary models — could reshape cosmology and the scientific method itself.
Professor JB Manchak proves that no amount of empirical data — even from every point in the universe — can determine its global structure. He introduces Heraclitus spacetimes (maximally asymmetric universes where local structure determines global structure), and draws surprising parallels between cosmic underdetermination and Zen Buddhist non-self.
