Anthropic 增长负责人："Claude 正在自己驱动增长"
Amol Avasari · Head of Growth, Anthropic
Anthropic 增长负责人 Amol Avasari 分享了公司 14 个月内从 $1B 到 $19B ARR 的增长故事、 用 Claude 自动化增长实验的 CASH 项目、PM 角色在 AI 时代的演变，以及他从严重脑损伤中 恢复并成为顶级增长领导者的个人经历。
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AI & Tech 20 集
An AI state of the union: We've passed the inflection point & dark factories are coming
Simon Willison · Open-source engineer & Django co-creator
Simon Willison (co-creator of Django, coined "prompt injection") talks with Lenny Rachitsky about the November 2025 inflection point when coding agents crossed a reliability threshold, the dark factory pattern where nobody writes or reads code, and the lethal trifecta of AI security risks.
Head of Claude Code: What happens after coding is solved | Boris Cherny
Boris Cherny · Head of Claude Code, Anthropic
Claude Code 一周岁。它的负责人 Boris Cherny 复盘从"内部 demo 只收到 2 个赞" 到"GitHub 4% 公开 commits、Anthropic 内部人均生产力 +200%"是怎么发生的， 并解释为什么他认为 coding 已经被解决、下一站是让模型自己想做什么、 以及怎么"为 6 个月后的模型"造产品。
OpenClaw: The Viral AI Agent that Broke the Internet - Peter Steinberger | Lex Fridman Podcast #491
Peter Steinberger · Creator of OpenClaw, founder of PSPDFKit
Peter Steinberger 讲他怎么在 1 小时内把 WhatsApp 接到 Claude Code 的 CLI, 做出了后来成为 GitHub 史上最快增长仓库的 OpenClaw。围绕这个故事展开的是 agentic engineering 的心法、self-modifying software、Moldbook 引发的 AI psychosis、改名大战、以及他从 PSPDFKit 13 年烧完到重新找回 building 乐趣 的整条弧线。最后谈到下一步可能加入 Meta 或 OpenAI。
State of AI in 2026: LLMs, Coding, Scaling Laws, China, Agents, GPUs, AGI | Lex Fridman Podcast #490
Sebastian Raschka, Nathan Lambert · 《Build a Large Language Model (From Scratch)》作者 + AI2 研究员 / RLHF 书作者
Lex Fridman 请来两位"一线做过模型、也写过书"的研究者做 2026 年初的 AI state-of-the-art 盘点: Sebastian Raschka 从 GPT-2 一路手撕到 Qwen3 / Gemma 3, 最擅长从架构里读故事;Nathan Lambert 是 AI2 研究员、RLHF 书作者、atom 项目 发起人,frontier 与 open-source 两边都站过。两人聊了 DeepSeek 时刻、Opus 4.5 神话、RLVR 的"假 aha"、scaling 的三个轴、AI 2027 的时间线推后、Anthropic $1.5B 和解、CUDA 的真护城河、atom project,一直到 100 年后世界的样子。
Terence Tao – How the world's top mathematician uses AI
Terence Tao · UCLA mathematician, Fields Medalist
当世最强的数学家谈他亲手用过 AI 之后的判断：想法生成的成本几乎归零， 但瓶颈搬到了 verification 这一侧；50 道 Erdős 问题被 AI 攻克之后随即陷入瓶颈； AI 像在黑暗中乱跳的机器人，能跨过低墙、爬不上悬崖；breadth × depth 才是 数学的下一步——但要先重设整个学术工作流。
Jensen Huang: NVIDIA — The $4 Trillion Company & the Future of AI
Jensen Huang · NVIDIA CEO
Jensen Huang 把 NVIDIA 的打法讲成一条推理链：从 extreme co-design 到四条 scaling law，从 CUDA 在 GeForce 上的存在主义赌博到 agentic 时代的 "iPhone of tokens"。他也谈到 TSMC、中国、 供应链、能源瓶颈，以及"intelligence is a commodity"的人生哲学。
Why most AI products fail: Lessons from 50+ AI deployments at OpenAI, Google & Amazon
Aishwarya Sranti & Kiriti Bottem · AI product consultants & OpenAI Codex engineer
Ash and Kiriti share hard-won lessons from 50+ AI product deployments across OpenAI, Google, and Amazon. They break down why AI products are fundamentally different from traditional software (non-determinism + agency-control tradeoff), introduce their CCCD framework for iterative AI development, and argue that pain — not speed to market — is the real competitive moat.
The rise of the professional vibe coder (a new AI-era job)
Lazar Yavanovich · Lovable Vibe Coding Engineer
Lovable 首位官方 Vibe Coding 工程师 Lazar Yavanovich 分享了一套完整的职业 vibe coding 方法论： 从平行构建 5 个项目获取 clarity，到 PRD 文档系统和 4x4 调试框架，再到为什么设计品味和判断力 将成为 AI 时代最稀缺的技能。
OpenAI's head of platform engineering on the next 12-24 months of AI | Sherwin Wu
Sherwin Wu · Head of Platform Engineering, OpenAI
OpenAI API 与开发者平台工程负责人 Sherwin Wu 分享了 AI 如何重塑软件工程、管理哲学、 创业生态，以及未来 12-24 个月模型能力和平台方向的展望。
The design process is dead. Here's what's replacing it. | Jenny Wen (head of design at Claude)
Jenny Wen · Head of Design, Claude (Anthropic)
Jenny Wen, head of design for Claude at Anthropic (previously director of design at Figma), discusses how AI is fundamentally transforming the design profession. She argues the traditional design process is dead, replaced by two modes: execution support (pairing with engineers) and short-horizon vision-setting. Topics include building trust through speed, three hiring archetypes for the AI era, the legibility framework, and why design managers need IC rotations.
From skeptic to true believer: How OpenClaw changed my life | Claire Vo
Claire Vo · 3x CPO, ChatPRD Founder, How I AI Host
Claire Vo shares her journey from vocal OpenClaw skeptic to running 9 specialized agents across 3 Mac Minis. She explains how management skills translate directly to agent management, demonstrates real use cases from sales automation to family logistics, and provides practical setup and security advice.
AI is critical for humanity's survival: Cisco President on the AI revolution | Jeetu Patel
Jeetu Patel · Cisco CPO & President
Cisco CPO/President Jeetu Patel discusses why AI is essential for humanity's survival given declining birth rates, how Cisco connects GPU clusters across data centers as critical AI infrastructure, and shares his six-part framework for building great companies.
Marc Andreessen: The real AI boom hasn't even started yet
Marc Andreessen · Co-founder of Andreessen Horowitz (a16z)
Marc Andreessen argues AI arrives at a miraculously well-timed moment — just as productivity growth has stagnated for 50 years and global population is declining. He unpacks the "Mexican standoff" between PMs, engineers, and designers, explains why task loss matters more than job loss, and makes the case for indeterminate optimism.
Elon Musk – "In 36 months, the cheapest place to put AI will be space"
Elon Musk · CEO of Tesla, SpaceX, xAI
Elon Musk 与 Dwarkesh Patel 长达 3 小时的深度对谈，涵盖太空 AI 数据中心（36 个月内最经济）、 Starship 每小时一次发射、月球质量驱动器、Terafab 自建芯片厂、Optimus 机器人的递归指数增长、 中美制造业竞争，以及 xAI "understand the universe" 使命与 AI 安全。
The real AI revolution isn't software. It's farms, mines, and trucks. | Qasar Younis
Qasar Younis · Applied Intuition CEO
Applied Intuition CEO Qasar Younis 首次公开访谈。他认为 AI 真正的影响不在软件开发， 而在农业、矿业、建筑和卡车运输等物理行业。对谈涵盖 Physical AI 路线、 中国竞争的误读、创始人的沉默哲学、以及一家近十年未花过融资的 $15B 公司如何运营。
Dylan Patel — The single biggest bottleneck to scaling AI compute
Dylan Patel · CEO, SemiAnalysis
SemiAnalysis CEO Dylan Patel walks through the entire AI compute supply chain, from $600B hyperscaler capex to the 3.5 EUV tools needed per gigawatt. He explains why semiconductors — not power — are the real bottleneck, and what that means for the US-China AI race, memory prices, and consumer electronics.
Dario Amodei — "We are near the end of the exponential"
Dario Amodei · Anthropic CEO
Anthropic CEO Dario Amodei 三年后再度做客 Dwarkesh Podcast，深度解析他为何认为 我们正接近 AI 指数增长的终点。从 2017 年的 Big Blob of Compute 假说到 country of geniuses in a data center 的 1-3 年预测，从 Anthropic 10x 年增长到算力采购的 生死赌局，从 AI 宪法的三层治理到独裁体制道德过时论。
We replaced our sales team with 20 AI agents — here's what happened next | Jason Lemkin (SaaStr)
Jason Lemkin · SaaStr Founder & CEO
Jason Lemkin shares how SaaStr went from a 10-person sales team to 1.2 humans and 20 AI agents with the same revenue output. He covers which sales roles will go extinct, how to train agents in 30 days, and why the future belongs to $250K SDRs managing 10 agents instead of 10 people.
Dario Amodei: Anthropic CEO on Claude, AGI & the Future of Humans & AI
Dario Amodei, Amanda Askell, Chris Olah · Anthropic CEO + Character lead + Interpretability co-founder
Lex Fridman 与 Anthropic 的三位核心人物同场对谈: CEO Dario Amodei 讲 scaling 假设、RSP 的 if-then 结构、"race to the top" 战略与 Machines of Loving Grace; character lead Amanda Askell 讲 Claude 的性格工程、sycophancy 与最优失败率; interpretability 共同创始人 Chris Olah 讲 features、circuits、superposition 和那个著名的 deception feature。三人从战略、产品、研究三个层面拼出 Anthropic 对 "AI inside" 的完整 stereo view。
Mind & Body 4 集
The Best Vitality & Health Protocols | Dr. Rhonda Patrick
Dr. Rhonda Patrick · Biomedical scientist, FoundMyFitness founder
Dr. Rhonda Patrick joins Andrew Huberman for a comprehensive deep-dive into evidence-based health protocols covering exercise (VILPA, strength training), gut-inflammation cascades, omega-3 as her top supplement, cortisol management, intermittent fasting mechanics, creatine for brain health, and her full supplement stack with dosages and rationale.
How Hormones Shape Sexual Orientation & Behavior | Dr. Marc Breedlove
Dr. Marc Breedlove · Michigan State University neuroscience professor
Dr. Marc Breedlove explains how prenatal testosterone shapes sexual orientation, the fraternal birth order effect, gay rams, brain sexual dimorphisms, and why sexual orientation is not a choice — through the lens of decades of biological research.
Cultivating Awe & Emotional Connection in Daily Life | Dr. Dacher Keltner
Dr. Dacher Keltner · UC Berkeley Psychology Professor & Greater Good Science Center Co-Director
Emotion scientist Dr. Dacher Keltner explains the neuroscience of awe — how shifting perception from "small to vast" triggers measurable health benefits including reduced inflammation, less pain, and better brain health years later. The conversation spans the expanded taxonomy of 20 facial expressions, the role of teasing and embarrassment in group bonding, the loneliness epidemic, music as the fastest path to collective consciousness, and practical awe design for cities and daily life.
Science-Based Meditation Tools to Improve Your Brain & Health | Dr. Richard Davidson
Dr. Richie Davidson · Professor of Psychology & Psychiatry, University of Wisconsin-Madison
Dr. Richie Davidson, a pioneer in meditation neuroscience, explains how just 5 minutes of daily meditation for 30 days produces measurable reductions in depression, anxiety, and inflammation. He introduces the concept of "the lactate of the mind" — the initial anxiety of meditation as an adaptation signal — and presents his four-pillar framework for human flourishing: awareness, connection, insight, and purpose.
Science 4 集
Quantum Mechanics Contradicts Itself (and He Proved It)
Renato Renner · Professor of Quantum Information, ETH Zurich
Professor Renato Renner of ETH Zurich explains his no-go theorem showing quantum theory contradicts itself when applied to observers who are themselves quantum systems. The conversation covers three incompatible assumptions (universality, consistency, single outcomes), a gravity-based escape route involving reference frame loops, the black hole information paradox, and why choosing an interpretation of quantum mechanics is ultimately an emotional decision.
Michael Nielsen – Why aliens will have a different tech stack than us
Michael Nielsen · Research fellow, writer, quantum computing pioneer
Michael Nielsen and Dwarkesh Patel explore how scientific progress actually happens — from the messy reality of falsification to hostile verification loops that mislead for decades. They discuss why the tech tree is far vaster than we realize, why alien civilizations would develop radically different technologies, and what this means for AI-accelerated science.
The "Inverse Problem" Of Dark Matter Is Insane
Dr. Jenny Wagner · Astrophysicist, Institute of Astronomy & Astrophysics / Helsinki Institute of Physics
Dr. Jenny Wagner explains why gravitational lensing data only constrains local properties of mass distributions, making every grand dark matter map a model-driven extrapolation. She argues the inverse problem approach — reasoning from data to necessary models — could reshape cosmology and the scientific method itself.
The Theorem That Proves Science Can't Know the Universe
JB Manchak · UC Irvine Professor of Logic & Philosophy of Science
Professor JB Manchak proves that no amount of empirical data — even from every point in the universe — can determine its global structure. He introduces Heraclitus spacetimes (maximally asymmetric universes where local structure determines global structure), and draws surprising parallels between cosmic underdetermination and Zen Buddhist non-self.
Business & Career 3 集
The art of influence: The single most important skill left that AI can't replace | Jessica Fain
Jessica Fain · VP Product @ Webflow
Jessica Fain, VP Product at Webflow and former chief of staff to two CPOs at Slack, unpacks the art and science of influencing executives — from tactical meeting techniques to building long-term trust. She argues influence is the single highest-leverage skill for product leaders, especially as AI commoditizes execution.
Negotiation Expert: How to stop leaving 40% of your comp on the table | Jacob Warwick
Jacob Warwick · Professional Negotiator
Jacob Warwick, a professional negotiator who has helped clients secure over $1 billion in additional comp, shares the psychology and tactics behind compensation negotiation. From simple pushbacks that yield 20% more to strategic approaches averaging 40% movement, he reveals how information asymmetry, emotional intelligence, and creative deal structures can transform careers.
Lenny Rachitsky: Behind the Scenes of Building a 1.2M-Subscriber Newsletter
Lenny Rachitsky · Newsletter creator & podcast host
Lenny Rachitsky's wife Michelle Rial turns the tables and interviews him about how he went from an Airbnb PM to building a 1.2 million subscriber newsletter and top-10 tech podcast. He shares never-before-told stories including a psychedelic experience that gave him confidence to write, the fraud crisis that nearly broke his business, and why he revises each post ~50 times.
Culture & History 1 集
Vikings, Ragnar, Berserkers, Valhalla & the Warriors of the Viking Age | Lex Fridman Podcast #495
Lars Brownworth · Historian, author of The Sea Wolves
历史学家 Lars Brownworth 用 1.5 小时把 793–1066 年的 Viking 时代拆给你看： 从 Lindisfarne 那场让欧洲修士相信"世界末日来了"的袭击，到长船 70–120 mi/day 的恐怖速度， 再到 Ragnar、Valhalla、Berserkers、Leif Erikson 的 Vinland、东到 Constantinople 的 Varangian Guard。最后落到一个反差：这个 destroyer 民族只用了三代人就变成 builder， 造出了 Normandy、Kievan Rus 与现代欧洲的雏形。
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